HOMOLOGY MODELING OF SUBCUTANEOUS FILARIASIS DHFR PROTEINS

Chemical shift guided homology modeling of larger proteins

We describe an alternate approach to protein structure determination that relies on experimental NMR chemical shifts, plus sparse NOEs if available. The newly introduced alignment method, POMONA, directly exploits the powerful bioinformatics algorithms previously developed for sequence-based homology modeling, but does not require significant sequence similarity. Protein templates, generated by...

Illustrating and homology modeling the proteins of the Zika virus

The Zika virus (ZIKV) is a flavivirus of the family Flaviviridae, which is similar to dengue virus, yellow fever and West Nile virus. Recent outbreaks in South America, Latin America, the Caribbean and in particular Brazil have led to concern for the spread of the disease and potential to cause Guillain-Barré syndrome and microcephaly. Although ZIKV has been known of for over 60 years there is ...

Homology modeling of membrane proteins: A critical assessment

Evaluation and validation of homology modeling protocols are indispensable for membrane proteins as experimental determination of their three-dimensional structure is an arduous task. The prediction ability of Modeller, MOE, InsightII-Homology and Swiss-PdbViewer (SPV) with different sequence alignments CLUSTALW, BLAST and 3D-JIGSAW have been assessed. The sequence identity of the target and te...

Subcutaneous filariasis in India--Possible indication of human Dirofilariasis.

Madam, I read with great interest the article by Naik et al1, concerning diagnosis of filariasis. The adult female patient was afebrile with no lymphadenopathy or organomegaly. The authors could not diagnose properly the species of the filarial worm. In recent years, numerous cases of human Dirofilariasis have been reported, indicating fast emergence of this zoonotic disease2. Of the eight huma...

Probabilistic protein homology modeling